The dysbiosis of gut microbiota in major depressive disorder and comorbidity with overweight/obesity: unraveling biomarkers and metabolic pathways from a microbial perspective
This study provides novel insights into the interplay between gut microbiota dysbiosis and metabolic perturbations in MDD. Despite intriguing associations between BMI and specific microbial taxa within the MDD group, the preliminary nature of these associations necessitates validation through larger cohorts, multi-omics approaches, and longitudinal designs.
Authors
- Bing Cao (ORCID: https://orcid.org/0000-0001-5963-2676)
- Chenxuan Lu
- Roger S. McIntyre (ORCID: https://orcid.org/0000-0003-4733-2523)
- Kayla M. Teopiz (ORCID: https://orcid.org/0000-0001-8429-6563)
- Lu Zhan (ORCID: https://orcid.org/0000-0003-1867-0304)
- Lailai Yan (ORCID: https://orcid.org/0000-0002-8554-9689)
Institutions
- Southwest University (CN)
- University of Toronto (CA)
- Peking University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical and Pharmaceutical College (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s12888-025-07388-w
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China