Somatostatin Ameliorates Corneal Nerve Abnormalities and Inflammation Through Regulation of Macrophage Activities in Dry Eye Disease
SOM230 alleviates nerve abnormalities in DED by suppressing inflammatory pathways (TNF-α, NF-κB) and promoting a shift in macrophage polarization from the pro-inflammatory M1 phenotype to the reparative M2 phenotype. These findings suggest that modulation of macrophage polarization is a crucial mechanism underlying the therapeutic effects of SOM230, highlighting its potential as a treatment strategy for nerve damage in DED.
Authors
- Yu Chai (ORCID: https://orcid.org/0009-0006-1037-944X)
- Yiteng Lu
- Qingye Zhang (ORCID: https://orcid.org/0000-0002-9596-590X)
- Yang Cao (ORCID: https://orcid.org/0000-0002-3552-9153)
- Jiaxu Hong (ORCID: https://orcid.org/0000-0001-9912-633X)
- Yuqing Wu (ORCID: https://orcid.org/0000-0003-4883-5982)
- Yunhong Zhang (ORCID: https://orcid.org/0000-0002-2899-5068)
- Xujiao Zhou (ORCID: https://orcid.org/0000-0002-9719-4889)
- Han Ye (ORCID: https://orcid.org/0000-0002-9119-4781)
- Xingyu Zhu (ORCID: https://orcid.org/0009-0001-8392-369X)
- Yirou Zhang
Institutions
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Shanghai Cell Therapy Research Institute (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1167/iovs.66.14.18
- Citations
- 1
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 1.88