<i>ESR1</i> -Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer
ESR1 mutations in breast cancer induce metabolic changes that trigger ferroptosis sensitivity, enabling ferroptosis inducers to enhance selective ER degraders' efficacy and positioning ACSL4 as a biomarker for guiding therapy in endocrine-resistant disease.
Authors
- Rania El Botty
- Nicla Lorito (ORCID: https://orcid.org/0000-0003-2354-2622)
- Alfredo Smiriglia (ORCID: https://orcid.org/0000-0001-6654-3962)
- Andrea Morandi (ORCID: https://orcid.org/0000-0002-9222-5332)
- Bruna Cerbelli (ORCID: https://orcid.org/0000-0001-5419-2309)
- Andrea Botticelli (ORCID: https://orcid.org/0000-0002-6425-9893)
- Gabriele Tani (ORCID: https://orcid.org/0009-0008-0510-3507)
- Marina Bacci (ORCID: https://orcid.org/0000-0001-8506-2179)
- Giuseppina Comito (ORCID: https://orcid.org/0000-0002-4614-067X)
- Angela Subbiani (ORCID: https://orcid.org/0000-0001-7184-0734)
- Lorenzo Livi (ORCID: https://orcid.org/0000-0002-7755-9422)
- Laura Sourd (ORCID: https://orcid.org/0000-0001-6010-7721)
- Marco Fiorillo (ORCID: https://orcid.org/0000-0002-8055-3259)
- Barbara Belletti (ORCID: https://orcid.org/0000-0003-2249-0285)
- Francesca Bonechi (ORCID: https://orcid.org/0009-0009-9420-7339)
- Ilenia Segatto (ORCID: https://orcid.org/0000-0001-5282-1028)
- Elisabetta Marangoni (ORCID: https://orcid.org/0000-0002-3337-6448)
- Elisabetta Romano (ORCID: https://orcid.org/0009-0002-0252-3780)
- Icro Meattini (ORCID: https://orcid.org/0000-0002-1861-2895)
- Assia Duatti (ORCID: https://orcid.org/0009-0009-0089-6058)
- Edoardo Pagliantini (ORCID: https://orcid.org/0009-0001-1449-1176)
- Giulia Gangarossa (ORCID: https://orcid.org/0009-0008-3375-4577)
Institutions
- Université Paris Sciences et Lettres (FR)
- Policlinico Umberto I (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Centro di Riferimento Oncologico (IT)
- University of Florence (IT)
- University of Calabria (IT)
- Institut Curie (FR)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1339
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00