lncRNA IGFL2-AS1 mediates NSCLC chemoresistance via YBX1-induced HSPA1A/RAP1 activation
This study demonstrated that the YBX1-modulated IGFL2-AS1/HSPA1A/RAP1 axis is aberrantly activated in lung cancer cells and is associated with unfavorable prognosis, highlighting its potential as a novel therapeutic target in clinical settings.
Authors
- Bingjie Cui (ORCID: https://orcid.org/0000-0002-5912-0344)
- Yong Yu (ORCID: https://orcid.org/0000-0003-1928-2514)
- Jingjing Qi (ORCID: https://orcid.org/0000-0002-9368-1882)
- Clemens A. Schmitt (ORCID: https://orcid.org/0000-0002-4731-2226)
- Jing Du
- Jiong Deng (ORCID: https://orcid.org/0000-0002-4489-7556)
- Hongliang Dong (ORCID: https://orcid.org/0000-0001-8259-249X)
- Nailiang Zhai (ORCID: https://orcid.org/0000-0003-0081-1711)
- Weiwei Chen (ORCID: https://orcid.org/0000-0002-1683-4785)
- Fei Wang (ORCID: https://orcid.org/0000-0001-6712-3468)
- Wenwen Lv
- Fangling Ning (ORCID: https://orcid.org/0000-0002-6697-2262)
- Cuilan Liu (ORCID: https://orcid.org/0000-0003-4879-7445)
- Yunxiu Xia
Institutions
- Johannes Kepler University of Linz (AT)
- Shandong University of Aeronautics (CN)
- Max Delbrück Center (DE)
- Humboldt-Universität zu Berlin (DE)
- Kepler Universitätsklinikum (AT)
- Binzhou People's Hospital (CN)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s11658-025-00808-5
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Binzhou Medical University