Activation of the zona incerta GABAergic circuit for the treatment of pain hypersensitivity in Parkinson’s disease mice model
Our results indicate that the ZI GABAergic neurons and their downstream projections to the VTA play crucial roles in modulating pain processing under both physiological conditions and during PD states. This research offers fresh perspectives on the PD pain mechanism. Considering our previous report indicating that stimulation of ZI GABAergic neurons improved motor performance in 6-OHDA-lesioned mice, we propose that the ZI may serve a dual regulatory function concerning both motor behavior and pain response associated with PD.
Authors
- Wenting Jia
- Le Qu (ORCID: https://orcid.org/0000-0003-1667-2453)
- Yanhong Liu (ORCID: https://orcid.org/0000-0002-6747-6834)
- Juntao Cui (ORCID: https://orcid.org/0000-0002-0168-6564)
- Junliang Qian (ORCID: https://orcid.org/0000-0001-7793-0984)
- Junxia Xie (ORCID: https://orcid.org/0000-0003-4187-7901)
- Limin Shi
- Yaying Shi
Institutions
- Qingdao University (CN)
- Qingdao Municipal Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s10194-025-02198-7
- Citations
- 2
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province