Integrative SMR and single cell & spatial analysis reveals the spatial heterogeneity and prognostic value of CASP9-mediated apoptotic pathways in clear cell renal cell carcinoma
Our study reveals that apoptosis, particularly CASP9-driven programs, defines a spatially organized, immunosuppressive malignant cell state in ccRCC. CASP9 acts as both a genetic driver and spatial regulator of tumor-macrophage interactions, contributing to disease progression. The CASP9-associated risk model demonstrates strong prognostic utility and highlights apoptosis as a promising therapeutic axis in ccRCC.
Authors
- 大也 田中 (ORCID: https://orcid.org/0000-0003-0511-9396)
- Lei Cai (ORCID: https://orcid.org/0000-0001-8535-530X)
- Wenchuan Shao
- Xiyi Wei (ORCID: https://orcid.org/0000-0002-0166-3194)
- Ninghong Song
- Zhigang Yu (ORCID: https://orcid.org/0000-0002-3093-4491)
- Xinghan Yan
Institutions
- Jiangsu Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1007/s12672-025-03798-0
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China