Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii
This study demonstrates that P450 monooxygenases from the malaria vectors can metabolise PAHs, highlighting the potential of these environmental pollutants selecting the P450s, driving insecticide resistance in field populations of major malaria vectors.
Authors
- Sulaiman S. Ibrahim (ORCID: https://orcid.org/0000-0003-0744-802X)
- Helen Irving (ORCID: https://orcid.org/0000-0002-1514-0909)
- Charles S. Wondji (ORCID: https://orcid.org/0000-0003-0791-3673)
- Hanafy M. Ismail (ORCID: https://orcid.org/0000-0002-9953-9588)
- Abdullahi Muhammad (ORCID: https://orcid.org/0000-0002-6438-4897)
- Mark J. I. Paine (ORCID: https://orcid.org/0000-0003-2061-7713)
Institutions
- Liverpool School of Tropical Medicine (GB)
- Ministry of Scientific Research and Innovation (CM)
- Bayero University Kano (NG)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s12864-025-12229-x
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Petroleum Technology Development Fund