Mechanistic effects of percutaneous needle fasciotomy combined with stretching on early-stage skeletal muscle fibrosis in rats: focus on the TGF-β1/Smad signaling pathway
Our findings from this animal model demonstrate that PNF was superior to Apu in alleviating early-stage skeletal muscle fibrosis over the short term, potentially via modulation of the TGF-β1/Smad signaling pathway, though long-term effects warrant further investigation.
Authors
- Wayne Jason Li
- Xinyi Zhao (ORCID: https://orcid.org/0000-0002-5673-6661)
- Min Lü (ORCID: https://orcid.org/0000-0001-6902-3751)
- Yi Zhang (ORCID: https://orcid.org/0009-0007-7340-3619)
- Han Zhang (ORCID: https://orcid.org/0000-0002-2684-512X)
- Jiahui Li (ORCID: https://orcid.org/0000-0003-4817-220X)
- Hanyu Zhang (ORCID: https://orcid.org/0009-0005-1008-5225)
- Rui Hu (ORCID: https://orcid.org/0000-0002-5987-4277)
Institutions
- Beijing Tongren Hospital (CN)
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Second People's Hospital of Yunnan Province (CN)
- China Association of Acupuncture-Moxibustion (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s13018-025-06400-z
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Beijing University of Chinese Medicine