Imidazole propionate ameliorates lipid metabolism in adipocytes to attenuate high-fat diet-induced obesity via PPAR signaling pathway
These findings demonstrate that ImP attenuates lipid accumulation by inhibiting the PPAR signaling pathway. As a gut microbial metabolite, ImP may offer therapeutic potential in preventing or treating HFD-induced obesity.
Authors
- Xirong Guo (ORCID: https://orcid.org/0000-0003-4873-8832)
- Zhongxiao Zhang (ORCID: https://orcid.org/0000-0002-5302-9515)
- Shan Huang (ORCID: https://orcid.org/0000-0003-1340-9158)
- Shan Xue (ORCID: https://orcid.org/0000-0002-9123-5133)
- Zhou Peng (ORCID: https://orcid.org/0000-0003-3612-0912)
- Liling Xu (ORCID: https://orcid.org/0000-0002-2095-0906)
- Juan Du (ORCID: https://orcid.org/0000-0003-2259-1895)
- Jianfang Gao
- Caiyu Lin
Institutions
- Bengbu Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Tongren Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s12944-025-02768-3
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China