Investigation of methylation profiles in Silver–Russell syndrome to explore episignatures
GWMA in SRS patients with different molecular etiologies identified no characteristic episignatures. Only methylation changes of CpGs within disease-responsible DMRs, not genome-wide methylation changes, occur in some SRS etiologies.
Authors
- Masayo Kagami (ORCID: https://orcid.org/0000-0003-3020-455X)
- Kazuki Yamazawa (ORCID: https://orcid.org/0000-0003-4895-2759)
- Tomoko Kawai (ORCID: https://orcid.org/0000-0001-8137-0334)
- Kaori Hara‐Isono
- Takanobu Inoue (ORCID: https://orcid.org/0000-0001-8495-5776)
- Akie Nakamura
- Keiko Matsubara (ORCID: https://orcid.org/0000-0001-6254-9216)
- Tomoko Fuke
- Maki Fukami (ORCID: https://orcid.org/0000-0001-9971-4035)
- Tsutomu Ogata
Institutions
- Hamamatsu University School of Medicine (JP)
- Tokyo Medical Center (JP)
- Keio University Hospital (JP)
- National Center For Child Health and Development (JP)
- Hamamatsu Medical Center (JP)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s13148-025-01993-y
- Citations
- 1
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Center for Child Health and Development
- Novartis Foundation
- Japan Agency for Medical Research and Development
- NOVARTIS Foundation (Japan) for the Promotion of Science
- Japan Society for the Promotion of Science