Serum urate levels and colorectal cancer risk: a prospective cohort study in of the UK biobank and a Mendelian randomization analysis
In this study, higher urate levels were associated with a reduced risk of CRC, and MR analysis supported a potential causal relationship between urate levels and CRC risk. However, further studies are needed to confirm causality and to investigate the potential subsite-specific effects of urate on CRC development.
Authors
- Kemin Xu
- Na Shen (ORCID: https://orcid.org/0000-0003-4362-9207)
- Yanjun Lu (ORCID: https://orcid.org/0000-0002-9518-9584)
- Hui Hu (ORCID: https://orcid.org/0009-0009-1798-2657)
- Qinwen Ba
- Yuhan Zhou (ORCID: https://orcid.org/0009-0008-3649-4184)
Institutions
- Hubei University of Chinese Medicine (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1007/s12672-025-03924-y
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00