The impact of STAiR18 on multiple myeloma survival rates
The study revealed that STAiR18 competed with endogenous miR-451a, and formed a novel positive-feedback loop of IL-6R/STAT3/JAK2 to promote proliferation of MM. These findings suggest that STAiR18 represents a promising novel therapeutic strategy for MM treatment.
Authors
- Jianyou Shi (ORCID: https://orcid.org/0000-0002-1026-0282)
- Haolin Wang (ORCID: https://orcid.org/0000-0002-1735-9525)
- Yajie Wu
- Feifei Che (ORCID: https://orcid.org/0000-0002-5183-1854)
- Ling Zhong (ORCID: https://orcid.org/0000-0003-3551-9921)
- Jiao Chen (ORCID: https://orcid.org/0000-0003-2367-4369)
- Shuai Zheng
- Jianhao Lin (ORCID: https://orcid.org/0000-0003-1830-9244)
- Yifei Gao (ORCID: https://orcid.org/0000-0003-1502-4016)
- Yingmiao Wu (ORCID: https://orcid.org/0009-0000-9793-0084)
- Ji Luo
Institutions
- University of Electronic Science and Technology of China (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s12967-025-07210-x
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Electronic Science and Technology of China