The diagnostic and prognostic value of miR-188-5p in intracranial aneurysm (IA) and its potential regulatory mechanism

MiR-188-5p was a biomarker for IA and its rupture. MiR-188-5p might assist IA progression by inducing VSMC phenotypic switching and cell damage. MiR-188-5p affected VSMCs by downregulating IL6ST. MiR-188-5p might be the potential target for predicting and controlling the development of IA.

Authors

Lei Shi (ORCID: https://orcid.org/0000-0003-2627-7588)
Liujia Ma (ORCID: https://orcid.org/0000-0001-6129-9518)
Wenjie Tang (ORCID: https://orcid.org/0000-0002-9752-4948)

Institutions

Fourth People’s Hospital of Jinan (CN)
Yan'an University (CN)
Jinan City People's Hospital (CN)
Shandong First Medical University (CN)
The Fifth People’s Hospital of Suzhou (CN)

Publication Details

Journal: Hereditas
Published: 2025-11-07
DOI: https://doi.org/10.1186/s41065-025-00593-3
Primary Topic: Intracranial Aneurysms: Treatment and Complications
Type: article
Field-Weighted Citation Impact: 0.00

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article

The diagnostic and prognostic value of miR-188-5p in intracranial aneurysm (IA) and its potential regulatory mechanism

Lei Shi, Liujia Ma, Wenjie Tang

Nov 7, 2025

Hereditas

Intracranial Aneurysms: Treatment and Complications

article

The diagnostic and prognostic value of miR-188-5p in intracranial aneurysm (IA) and its potential regulatory mechanism

Lei Shi, Liujia Ma, Wenjie Tang

November 7, 2025article en

Abstract

MiR-188-5p was a biomarker for IA and its rupture. MiR-188-5p might assist IA progression by inducing VSMC phenotypic switching and cell damage. MiR-188-5p affected VSMCs by downregulating IL6ST. MiR-188-5p might be the potential target for predicting and controlling the development of IA.

HereditasVol. 162(1)

Fourth People’s Hospital of Jinan (CN), Yan'an University (CN), Jinan City People's Hospital (CN), Shandong First Medical University (CN), The Fifth People’s Hospital of Suzhou (CN)

Openalex Percentile: Top 54%

Intracranial Aneurysms: Treatment and Complications

DOI Open Access PDF OpenAlex

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The diagnostic and prognostic value of miR-188-5p in intracranial aneurysm (IA) and its potential regulatory mechanism — Lei Shi, Liujia Ma, et al. · Hereditas (2025) | TGRS Research Map | TGRS