High Mobility Group Box 1 Protein as a Biomarker in Adult Attention Deficit Hyperactivity Disorder

In our study, the finding that HMGB1 serum levels were higher in adult ADHD patients compared to healthy controls supports the hypothesis that chronic low-grade inflammation, which is both driven and detected by HMGB1, may be associated with ADHD through the possibility of causing neurodevelopmental disorders. It is known that HMGB1 is effective in the diagnosis and prognosis of immune system diseases. Therefore, our results show that HMGB1 may be related to the pathophysiology of ADHD.