RRM2 contributes to pathogenic phenotype of fibroblast-like synoviocytes by activating NF-κB signaling and inhibiting ferroptosis in rheumatoid arthritis
RRM2 inhibits ferroptosis and enhances the pathogenic behavior of RA FLSs through activation of the NF-κB pathway, highlighting its pivotal contribution to RA development.
Authors
- Linqi Zhang (ORCID: https://orcid.org/0000-0003-4931-509X)
- Qiyong Zhong (ORCID: https://orcid.org/0009-0004-9843-5260)
- J. P. Zheng
- Zhibing Wang (ORCID: https://orcid.org/0000-0001-9599-069X)
Institutions
- Sichuan Mianyang 404 Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s13018-025-06417-4
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04