iRGD-modified co-loaded curcumin piperine liposomes inhibit angiogenesis in non-small cell lung cancer through the VEGFR2/P38/MK2 signaling axis
iRGD-LP-CUR-PIP reduces tumor angiogenesis and affects tumor growth by inhibiting the VEGFR2/P38/MK2 pathway. Among them, CUR affects VEGF and PIP may affect CTR1, which in turn affects CTR1-VEGFR2 co-internalization and downstream signaling pathways. These changes result in enhanced anti-tumor activity by CUR-PIP binding, and the best anti-tumor activity was observed in the iRGD-LP-CUR-PIP group compared with the other groups.
Authors
- Mingfei Wang
- Jin-Ying Lin (ORCID: https://orcid.org/0000-0003-0946-9924)
- Yiming Zhuang (ORCID: https://orcid.org/0000-0001-9482-5289)
- Hongmin Yu
- Xunhua Huang
- Yinghao Wang (ORCID: https://orcid.org/0000-0002-1928-0538)
- Jiayuan Chen (ORCID: https://orcid.org/0000-0003-2586-8626)
- Yongzhong Chen (ORCID: https://orcid.org/0000-0003-2254-9873)
- Meixia Huang
- Yingzheng Wang (ORCID: https://orcid.org/0009-0006-1570-3624)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1007/s12672-025-03922-0
- Citations
- 2
- Primary Topic
- Piperaceae Chemical and Biological Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.11