Downregulation of HDGF inhibits tumorigenic phenotypes of hypopharyngeal squamous cell carcinoma by suppressing the AKT/mTOR/VEGF pathway
Our findings establish HDGF as a key promoter of HSCC progression through dual regulation of EMT and AKT/mTOR/VEGF pathways, suggesting its potential as a therapeutic target. These results provide mechanistic insights for developing HDGF-targeted strategies against this lethal malignancy, warranting further clinical exploration.
Authors
- Qiang Zhang (ORCID: https://orcid.org/0000-0001-5817-9494)
- Jiahao Shan (ORCID: https://orcid.org/0000-0002-7941-9933)
- Yang Han (ORCID: https://orcid.org/0000-0001-6242-3285)
- Ziyang Liu (ORCID: https://orcid.org/0000-0003-3283-2672)
- Feilong Yang (ORCID: https://orcid.org/0000-0001-5939-4110)
- Xusheng Du
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Inner Mongolia People's Hospital (CN)
- Ningxia Medical University (CN)
- Yueyang Hospital (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fonc.2025.1683145
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Ningxia Province