CagA-positive Helicobacter pylori may be associated with current infection of clonorchiasis

This study aims to explore the relationship between Helicobacter pylori (H. pylori) infection, particularly CagA-positive strains, and Clonorchiasis. A total of 309 civil servants who underwent health check-ups and 73 hospitalized patients with Clonorchiasis from May 2019 to April 2023 were included. A control group of 100 healthy individuals matched by age, gender, and residence was included. H. pylori and Clonorchiasis antibodies in civil servants were detected using ELISA. Western blotting was used to identify H. pylori strains in hospitalized patients. Among civil servants, H. pylori and Clonorchiasis antibody positivity rates were 43.7% and 23.9%, respectively. H. pylori antibody positivity was comparable between those with (45.9%) and without Clonorchiasis (43.0%) infection. H. pylori infection among Clonorchiasis patients (61.6%) was slightly higher than in healthy controls (44.0%). Multifactorial analysis identified consuming raw fish (61.145; 22.263-167.93; 0.000) and CagA + H. pylori infection (3.7; 1.233-11.103; 0.020) as independent risk factors for Clonorchiasis. The rate of CagA + H. pylori infection is significantly higher in patients with Clonorchiasis than in healthy individuals. CagA + H. pylori infection and a history of consuming raw fish are independent risk factors for current Clonorchiasis.