The role of the infrapatellar fat pad in osteoporotic knee osteoarthritis: bone-fat crosstalk: cross-sectional studies

Our results identify a pathophysiological triad of (1) IPFP fibrosis/hypervascularization, (2) systemic hypertriglyceridemia, and (3) low BMD that collectively accelerates structural degeneration and symptom progression in knee OA. While genetic and biomechanical factors initiate OA pathogenesis, these acquired metabolic-inflammatory mechanisms represent tractable therapeutic targets for modifying disease evolution in established OA, particularly with OP comorbidity.