Cucurbitacin E inhibits M1 macrophage polarization and attenuates rheumatoid arthritis: a multi-omics analysis and experimental validation
CuE inhibits M1 macrophage polarization and related pathways, offering a promising RA treatment strategy. The identified biomarkers may serve as diagnostic and therapeutic targets. Future research should validate CuE's clinical effects.
Authors
- Lin Yang (ORCID: https://orcid.org/0000-0002-5124-8650)
- Haolan Xiong (ORCID: https://orcid.org/0000-0002-1440-4095)
- Fuming Wang (ORCID: https://orcid.org/0000-0002-0834-1390)
- Shenglu Cao
- Xiaofang Hu (ORCID: https://orcid.org/0000-0003-3764-2640)
- Gang Wang (ORCID: https://orcid.org/0000-0002-2450-9536)
Institutions
- Shenzhen University (CN)
- Nanfang Hospital (CN)
- ShenZhen People’s Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s13018-025-06332-8
- Primary Topic
- Advances in Cucurbitaceae Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00