Negative Correlation Between Secreted Phosphoprotein 1 and the Treg/Th17 Ratio in Non-Valvular Atrial Fibrillation
Our findings suggest that elevated SPP1 levels disrupt the Treg/Th17 cell balance in NVAF patients, promoting inflammation and fibrosis. These findings indicate that SPP1 represents a promising therapeutic target for the prevention and management of NVAF.
Authors
- Yahui Li (ORCID: https://orcid.org/0000-0002-3820-4020)
- Chaojun Yang (ORCID: https://orcid.org/0000-0003-2617-8352)
- Bo Fu (ORCID: https://orcid.org/0009-0001-3169-4119)
- Yifan Huang (ORCID: https://orcid.org/0000-0001-9777-4237)
- Zhixing Fan (ORCID: https://orcid.org/0000-0002-3116-4580)
- Jingyi Wu (ORCID: https://orcid.org/0000-0002-6970-911X)
Institutions
- China Three Gorges University (CN)
- Xianning Central Hospital (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Second Hospital of Yichang (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
Publication Details
- Journal
- Reviews in Cardiovascular Medicine
- Published
- 2025-10-28
- DOI
- https://doi.org/10.31083/rcm44147
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- National Science and Technology Major Project