Pharmacokinetics, pharmacodynamics, and local tolerance at injection site of penicillin and gentamicin administered by intravenous regional limb perfusion in standing horses: comparison between weightbearing and flexed limbs
These findings suggest that daily IVRLP with NaBP (7,333 IU/kg of BP) could be an effective treatment for distal limb infections caused by susceptible bacteria with a MIC of ≤ 2 µg/mL, with only mild local inflammation at the injection site. IVRLP with 2.2 mg/kg gentamicin appears effective for treating infections involving susceptible bacteria with an MIC of ≤ 16 µg/mL. Performing IVRLP on a weightbearing limb resulted in higher antibiotic exposure in the metacarpophalangeal joint and better tolerance than the flexed limb method.
Authors
- Marlène Z. Lacroix (ORCID: https://orcid.org/0000-0002-6981-8340)
- Alain Bousquet‐mélou (ORCID: https://orcid.org/0000-0002-7661-4311)
- Béatrice B. Roques (ORCID: https://orcid.org/0000-0001-8229-437X)
- Élodie Lallemand (ORCID: https://orcid.org/0000-0001-5910-4611)
- Michel Guillot (ORCID: https://orcid.org/0000-0001-9072-8481)
- C. Mespoulhès‐Rivière
Institutions
- École Nationale Vétérinaire d'Alfort (FR)
- École Nationale Vétérinaire de Toulouse (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s12917-025-04936-0
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00