Methylenetetrahydrofolate Reductase and Methionine Synthase Reductase Polymorphisms: Genetic Predictors of Congenital Heart Disease Subtypes

<i>MTHFR</i>c.677C>Tand <i>MTRR</i> c.66A>Gpolymorphisms are associated with increased CHD risk, particularly in VSD, ASD, and PDA. The higher prevalence of T and G alleles in CHD cases suggests their potential role as genetic risk factors, emphasizing their relevance in CHD susceptibility and risk assessment.

Authors

Akhil Sharma (ORCID: https://orcid.org/0000-0002-5798-5889)
Shalini Tripathi (ORCID: https://orcid.org/0000-0003-0805-7370)
Shally Awasthi (ORCID: https://orcid.org/0000-0003-1254-9802)
Amita Jain (ORCID: https://orcid.org/0000-0003-3195-0220)
Sumedha Tripathi

Institutions

King George's Medical University (IN)

Publication Details

Journal: Cureus
Published: 2025-11-07
DOI: https://doi.org/10.7759/cureus.96291
Primary Topic: Folate and B Vitamins Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Methylenetetrahydrofolate Reductase and Methionine Synthase Reductase Polymorphisms: Genetic Predictors of Congenital Heart Disease Subtypes

Akhil Sharma, Shalini Tripathi, Shally Awasthi, Amita Jain et al.

Nov 7, 2025

Cureus

Folate and B Vitamins Research

article

Methylenetetrahydrofolate Reductase and Methionine Synthase Reductase Polymorphisms: Genetic Predictors of Congenital Heart Disease Subtypes

Akhil Sharma, Shalini Tripathi, Shally Awasthi, Amita Jain, Sumedha Tripathi

November 7, 2025article en

Abstract

<i>MTHFR</i>c.677C>Tand <i>MTRR</i> c.66A>Gpolymorphisms are associated with increased CHD risk, particularly in VSD, ASD, and PDA. The higher prevalence of T and G alleles in CHD cases suggests their potential role as genetic risk factors, emphasizing their relevance in CHD susceptibility and risk assessment.

CureusVol. 17(11)

King George's Medical University (IN)

Openalex Percentile: Top 53%

Folate and B Vitamins Research

DOI Open Access PDF OpenAlex

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