Methionine induced placental angiogenesis through activating WNT3A/CTNNB1-PIGF-VEGFR1 pathway
This study elucidated that methionine promoted placental angiogenesis through the ROS-WNT3A/CTNNB1-PIGF-VEGFR1 axis, providing new therapeutic targets for pregnancy complications.
Authors
- Xiangfang Zeng (ORCID: https://orcid.org/0000-0002-0245-989X)
- Jiayu Tu (ORCID: https://orcid.org/0009-0004-8432-1529)
- Yiping Zou (ORCID: https://orcid.org/0000-0003-2880-2147)
- Linlu Zhao (ORCID: https://orcid.org/0000-0003-2676-9793)
- Shuang Cai (ORCID: https://orcid.org/0000-0003-4327-7723)
- Xiangzhou Zeng (ORCID: https://orcid.org/0000-0002-3371-9674)
- Shiyan Qiao (ORCID: https://orcid.org/0000-0003-2268-3220)
- Quan Shuang (ORCID: https://orcid.org/0000-0002-9070-2895)
- Yiwen Yang (ORCID: https://orcid.org/0000-0003-0145-7283)
- Ziqi Wang (ORCID: https://orcid.org/0000-0002-7558-1394)
Institutions
- Shenzhen Institute of Information Technology (CN)
- Shenzhen University (CN)
- Ministry of Agriculture (ID)
- Liaoning Academy of Agricultural Sciences (CN)
- Sericultural Research Institute (CN)
- Feed Research Institute (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s12964-025-02488-2
- Citations
- 1
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation