α‐Synuclein seed amplification assay in Lewy body dementia versus Alzheimer's disease
CSF and skin biopsies show high diagnostic accuracy for α-synuclein, demonstrating good concordance.Strong correlations exist between core symptoms of DLB and pathological α-synuclein.A very high sensitivity of hyposmia for pathological α-synuclein is observed.A novel proof-of-concept is offered for the potential detection of pathological α-synuclein in urine, marking the first such comparative analysis between patients with DLB and AD.
Authors
- Christian Pedersen (ORCID: https://orcid.org/0000-0002-3929-0936)
- Remarh Bsoul (ORCID: https://orcid.org/0000-0001-6574-8093)
- Kristian Steen Frederiksen (ORCID: https://orcid.org/0000-0001-5124-4417)
- Marie Bruun (ORCID: https://orcid.org/0000-0002-1066-1035)
- Steen Gregers Hasselbalch (ORCID: https://orcid.org/0000-0003-4750-4911)
- Eva Løbner Lund (ORCID: https://orcid.org/0000-0002-6291-5893)
- Anja Hviid Simonsen (ORCID: https://orcid.org/0000-0002-5461-162X)
- Aušrinė Areškevičiūtė (ORCID: https://orcid.org/0000-0003-0202-9942)
- Christian von Buchwald (ORCID: https://orcid.org/0000-0001-6753-8129)
- Kasper Aanæs (ORCID: https://orcid.org/0000-0002-7353-0817)
- Oskar McWilliam (ORCID: https://orcid.org/0000-0001-9728-8773)
- Magne Bech (ORCID: https://orcid.org/0009-0003-6471-0511)
- Ida S. B. Andersen
- Gunhild Waldemar
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70203
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Innovationsfonden
- Aase og Ejnar Danielsens Fond
- Eisai
- Novo Nordisk
- Rigshospitalet
- Harboefonden
- Kong Christian den Tiendes Fond
- Grosserer L. F. Foghts Fond