Allergen Sensitization Profiles and the Diagnostic Value of Total IgE, Eosinophil and Basophil Levels in Predicting Atopy in Allergic Diseases in Children

Object/ve: Allergy Fs a hypersensFtFvFty reactFon trFggered by varFous factors through FmmunologFcal mechanFsms.Elevated serum total IgE and perFpheral blood eosFnophFl levels are commonly observed Fn allergFc dFseases; however, these bFomarkers are not specFfFc to allergy.ThFs study aFmed to evaluate the dFagnostFc value of serum total IgE, eosFnophFl, and basophFl levels Fn predFctFng atopy.Method: AtopFc and non-atopFc patFents under 18 years of age dFagnosed wFth atopFc dermatFtFs, food allergy, allergFc rhFnFtFs, or asthma.werecompared Fn terms of serum total IgE levels, eosFnophFl, and basophFl counts.Results: A total of 673 patFents FncludFng 406 (60.3%) atopFc and 267 (39.7%) non-atopFc cases constFtuted the study populatFon.Most frequently sensFtFzatFon developed to egg Fn atopFc dermatFtFs, and food allergy, to tree pollens Fn allergFc rhFnFtFs, and to house dust mFte Fn asthma.Elevated total IgE levels were sFgnFfFcantly assocFated wFth atopy Fn patFents wFth allergFc rhFnFtFs and asthma, wFth odds ratFos of 3.33 and 16.37, respectFvely (p<0.001).The optFmal predFctFve cut-off value of serum total IgE for atopFc asthma was calculated as 108.5 kU/L, wFth a sensFtFvFty of 85.6% and specFfFcFty of 76.6%.SFmFlarly, a sFgnFfFcant assocFatFon was observed between eosFnophFlFa and atopy Fn allergFc rhFnFtFs and asthma, but not Fn atopFc dermatFtFs.Conclus/ons: Our fFndFngs suggest that serum total IgE Fs a sensFtFve and specFfFc bFomarker for predFctFng atopy Fn patFents wFth asthma.