A biofluid-repellent nanograss coating enhances flow of protein solutions and preserves transparency of glass capillaries upon exposure to blood

A transparent and superhydrophobic (SHB) nanograss coating makes glass capillaries repellent toward protein solutions and blood. The coating is fabricated using atomic layer deposited alumina which is converted into grass-like alumina (GLA) by hot water treatment (HWT). The resulting tubes are transparent and highly repellent towards water and protein solutions (sliding angle <6° for a concentrated albumin solution). The biofluid repellence of the coating reduces hydraulic resistances for protein-rich biofluids, including fetal bovine serum, by 0-50% with the strongest effect for the smallest tubes and lowest Reynolds numbers. This work addresses a knowledge gap where previous studies have mostly focused on pure water for the drag reduction effect. The tubes also show a promising ability to stay clean and transparent on short term exposure to blood, unlike unmodified glass or polymer controls.

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Publication Details

Journal
Nanoscale Advances
Published
2025-11-07
DOI
https://doi.org/10.1039/d5na00433k
Primary Topic
Surface Modification and Superhydrophobicity
Type
article
Field-Weighted Citation Impact
0.00

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article

A biofluid-repellent nanograss coating enhances flow of protein solutions and preserves transparency of glass capillaries upon exposure to blood

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A biofluid-repellent nanograss coating enhances flow of protein solutions and preserves transparency of glass capillaries upon exposure to blood

Sami Franssila, Nicholas Addy-Tayie, Christoffer Kauppinen, Heikki A. Nurmi, Ville P. Jokinen, Seyed Mehran Mirmohammadi, Sami Puustinen, Juho Leskinen, Robin H. A. Ras, Mohammad Awashra, Mubashir Hussain, Rosa Peltola
article en

Abstract

A transparent and superhydrophobic (SHB) nanograss coating makes glass capillaries repellent toward protein solutions and blood. The coating is fabricated using atomic layer deposited alumina which is converted into grass-like alumina (GLA) by hot water treatment (HWT). The resulting tubes are transparent and highly repellent towards water and protein solutions (sliding angle <6° for a concentrated albumin solution). The biofluid repellence of the coating reduces hydraulic resistances for protein-rich biofluids, including fetal bovine serum, by 0-50% with the strongest effect for the smallest tubes and lowest Reynolds numbers. This work addresses a knowledge gap where previous studies have mostly focused on pure water for the drag reduction effect. The tubes also show a promising ability to stay clean and transparent on short term exposure to blood, unlike unmodified glass or polymer controls.

Nanoscale AdvancesVol. 8(1)
University of Eastern Finland (FI), Kuopio University Hospital (FI), Eastern Finland Laboratory Center (FI), VTT Technical Research Centre of Finland (FI), Aalto University (FI)
Finska Läkaresällskapet
Openalex Percentile: Top 69%
Surface Modification and Superhydrophobicity
DOIOpen Access PDFOpenAlex
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