High-intensity running exercise promotes knee meniscal damage via the PI3K/AKT/mTOR axis
These observations demonstrate that prolonged and excessive mechanical stress may contribute to meniscal damage or degeneration through activation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) axis.
Authors
- Daozhang Cai (ORCID: https://orcid.org/0000-0003-2294-5411)
- Juncheng Yao (ORCID: https://orcid.org/0000-0001-9490-4577)
- Jianying Pan (ORCID: https://orcid.org/0000-0003-4761-4715)
- Guangxin Huang (ORCID: https://orcid.org/0000-0002-1277-9141)
- Huabin Chen (ORCID: https://orcid.org/0000-0002-6263-7002)
- Xuan Wang (ORCID: https://orcid.org/0000-0003-0639-2044)
- Haolin Ke (ORCID: https://orcid.org/0000-0002-7463-831X)
- Yan Shao (ORCID: https://orcid.org/0000-0001-6940-671X)
- Chun Zeng (ORCID: https://orcid.org/0000-0002-5682-1452)
- Zhe Li (ORCID: https://orcid.org/0009-0001-2553-9438)
Institutions
- Chinese University of Hong Kong (HK)
- Hong Kong Science and Technology Parks Corporation (HK)
- Third Affiliated Hospital of Southern Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1302/2046-3758.1411.bjr-2024-0535.r1
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00