Preoperative accelerated hypofractionated radiotherapy (PHYPORT): state of art and potential clinical application

Hypofractionation is a radiotherapy regimen that uses fewer fractions with higher doses with respect to conventional regimen. It can reduce overall treatment time and costs. Preoperative accelerated hypofractionated radiotherapy (PHYPORT) is a new approach in which radiation therapy is delivered in fewer, larger doses over a shorter period of time before surgery and it can be used to shrink tumours before surgical removal in some cancers. The choice of hypofractionated radiotherapy depends on the type of tumour, its localization and total target volume. Also, it is important to assess the potential benefits and risks of higher radiation doses. PHYPORT could be a more convenient and cost-effective option, but its effectiveness is unclear. This review assesses the use of PHYPORT in cancer treatment.