Safety and Immunogenicity of an rVSV Lassa Fever Vaccine Candidate
The rVSVΔG-LASV-GPC vaccine resulted in transient local and systemic reactogenicity events but no hearing loss or serious adverse events. The vaccine had immunogenicity over a wide dose range in healthy adults in the United States and Liberia. (Funded by the Coalition for Epidemic Preparedness Innovations and the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov number, NCT04794218; Pan African Clinical Trials Registry number, PACTR2021106625781067.).
Authors
- S. A. Sewell
- John McCullough
- Marija Zaric (ORCID: https://orcid.org/0000-0002-0569-6049)
- Burc Barin
- Michelle Engelbrecht (ORCID: https://orcid.org/0000-0002-3970-0552)
- Julie Blie
- Irina Maljkovic Berry (ORCID: https://orcid.org/0000-0001-8555-5352)
- R. N. Varma (ORCID: https://orcid.org/0009-0002-9722-1442)
- Arianna Marini (ORCID: https://orcid.org/0000-0003-3416-7362)
- Devin J Hunt (ORCID: https://orcid.org/0000-0002-2248-9180)
- Nahid Keshavarzi (ORCID: https://orcid.org/0000-0003-4817-4053)
- Matthew Ward
- Jennifer Lehrman
- Johan Vekemans (ORCID: https://orcid.org/0000-0002-3325-9073)
- Pat Fast (ORCID: https://orcid.org/0000-0001-9991-0351)
- Dagna Laufer
- Barthalomew Wilson
- Peter Hayes (ORCID: https://orcid.org/0000-0002-1251-934X)
- Kathleen A. Walker
- Natalia Fernández (ORCID: https://orcid.org/0000-0002-4213-079X)
- Elizabeth S. Higgs
- Faith Sigei (ORCID: https://orcid.org/0000-0001-7582-3296)
- Morolayo A. Ayorinde
- Eddy Sayeed
- Patrick Faley
- Elissa Malkin (ORCID: https://orcid.org/0000-0003-0943-5433)
- Fahimah Amini (ORCID: https://orcid.org/0000-0003-0799-4207)
- Vincent Philiponis (ORCID: https://orcid.org/0000-0003-2495-2498)
- Lindsey Robert Baden (ORCID: https://orcid.org/0009-0004-1752-1926)
- Rachel Bromell
- Elvis Towalid
- David Fitzpatrick (ORCID: https://orcid.org/0009-0002-3007-6818)
- Swati B. Gupta
- Heejin Yun (ORCID: https://orcid.org/0000-0003-0435-7253)
- Gaudensia Mutua (ORCID: https://orcid.org/0000-0002-5817-8843)
- Mark Kieh
- Christopher L. Parks (ORCID: https://orcid.org/0000-0002-2066-4483)
- Hema Pindolia
- Franklin Tokpah
- Cecelia Wisseh
- Swapnil Hadawale
- Shobhna Gopal Truter
- Mariette Malherbe
Institutions
- Brigham and Women's Hospital (US)
- International AIDS Vaccine Initiative (US)
- University of Liberia (LR)
- George Washington University (US)
- East–West Center (US)
- Emmes (United States) (US)
- National Institute of Allergy and Infectious Diseases (US)
- East West Medical Research Institute (US)
- George Washington University Virginia Campus (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1056/nejmoa2501073
- Citations
- 1
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40