HERC4 downregulates KRT19 to promote lung adenocarcinoma, migration, invasion and EMT
KRT19 downregulation promoted LUAD cell EMT, enhancing metastatic potential. HERC4 functioned as an upstream regulator that suppresses KRT19 expression by promoting its ubiquitination.
Authors
- Ziyang Feng (ORCID: https://orcid.org/0000-0002-2209-0217)
- Minghui Peng
- Hao-Jia Sun
- Xuewen Liu (ORCID: https://orcid.org/0000-0003-1947-1542)
- Hua Fu (ORCID: https://orcid.org/0000-0002-1105-9644)
Institutions
- Central South University (CN)
- Xiangyang Central Hospital (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.tranon.2025.102593
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00