Multiple Elective Surgeries and Cord Blood Transplantation for Multi-refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

A 42-year-old woman was diagnosed with monomorphic epithelial-type intestinal T-cell lymphoma (MEITL) following small bowel endoscopy. The patient subsequently underwent a small bowel resection to prevent perforation. Bowel lesions progressed shortly after completion of first-line chemotherapy. Although four different salvage regimens were attempted, they were refractory, and both bowel and ovarian lesions progressed. Partial jejunal resection was performed during the fifth salvage regimen, followed by oophorectomy. After achieving complete remission, she underwent cord blood transplantation and remained alive 37 months after the diagnosis. Integration of elective surgery and allogeneic transplantation may be a treatment option for relapsed or refractory MEITL.

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Publication Details

Journal
Internal Medicine
Published
2025-01-01
DOI
https://doi.org/10.2169/internalmedicine.5721-25
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
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article

Multiple Elective Surgeries and Cord Blood Transplantation for Multi-refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

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Internal Medicine
Lymphoma Diagnosis and Treatment
article

Multiple Elective Surgeries and Cord Blood Transplantation for Multi-refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma

Rie Ito, Naoki Uchida, Harunobu Tahara, Shingo Kurahashi, Yutaro Suzuki, Yu Nakashima, Yurika Yamada, Miki Watanabe, Naoto Imoto, M. Nakashima
article en

Abstract

A 42-year-old woman was diagnosed with monomorphic epithelial-type intestinal T-cell lymphoma (MEITL) following small bowel endoscopy. The patient subsequently underwent a small bowel resection to prevent perforation. Bowel lesions progressed shortly after completion of first-line chemotherapy. Although four different salvage regimens were attempted, they were refractory, and both bowel and ovarian lesions progressed. Partial jejunal resection was performed during the fifth salvage regimen, followed by oophorectomy. After achieving complete remission, she underwent cord blood transplantation and remained alive 37 months after the diagnosis. Integration of elective surgery and allogeneic transplantation may be a treatment option for relapsed or refractory MEITL.

Internal Medicine
Nagoya University Hospital (JP), Fujita Health University Hospital (JP), Japanese Red Cross Nagoya Daiichi Hospital (JP), Toyohashi Municipal Hospital (JP)
Openalex Percentile: Top 54%
Lymphoma Diagnosis and Treatment
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