Recurrent IgA1-λ-Type PGNMID Achieving Remission with Conventional Immunosuppressive Therapy: A Case Report
A 58-year-old man was admitted to our hospital in April 2013 with elevated serum creatinine levels, proteinuria, and hematuria. A renal biopsy revealed membranous proliferative glomerulonephritis-like changes. Immunofluorescence showed IgA1 and λ light chain deposits along the capillary walls, confirming IgA-λ type proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Complete remission was achieved with glucocorticoid monotherapy in December 2013. After a relapse in April 2021, immunosuppressive treatment, including intravenous cyclophosphamide and subsequent mycophenolate mofetil, led to a complete remission. This case indicates that conventional immunosuppressive therapy may be effective for IgA-type PGNMID.
Authors
- Izaya Nakaya (ORCID: https://orcid.org/0000-0002-0792-6514)
- Kingo Chida
- Yuta Ishizuka
- Machi Kiyohara
- Takashi Takahashi (ORCID: https://orcid.org/0000-0003-0615-7001)
- Atsushi Oura
- Yuki Nakamura (ORCID: https://orcid.org/0000-0003-4931-2489)
- Kohei Matsumoto (ORCID: https://orcid.org/0000-0002-7299-1048)
- H Kamei
- T Kyo
Institutions
- Iwate Prefectural Central Hospital (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2169/internalmedicine.6357-25
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00