A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy
In this prespecified interim analysis, treatment with atacicept resulted in a significantly greater reduction in proteinuria than placebo at week 36 in patients with IgA nephropathy. (Funded by Vera Therapeutics; ORIGIN 3 ClinicalTrials.gov number, NCT04716231.).
Authors
- Dana V. Rizk (ORCID: https://orcid.org/0000-0002-6877-2811)
- Necmi Eren (ORCID: https://orcid.org/0000-0002-2708-3470)
- Robert Brenner (ORCID: https://orcid.org/0000-0002-1036-8031)
- Beom Seok Kim (ORCID: https://orcid.org/0000-0002-5732-2583)
- Tom Doan
- Vivekanand Jha (ORCID: https://orcid.org/0000-0002-8015-9470)
- Adrian Liew (ORCID: https://orcid.org/0000-0002-0963-6270)
- Hitoshi Suzuki (ORCID: https://orcid.org/0000-0002-8382-4245)
- Atanu Kumar Pal (ORCID: https://orcid.org/0000-0001-7003-6031)
- Jonathan Barratt (ORCID: https://orcid.org/0000-0002-9063-7229)
- Richard Phoon (ORCID: https://orcid.org/0000-0001-9976-2774)
- Richard Lafayette (ORCID: https://orcid.org/0000-0003-3906-7934)
- Kirk N. Campbell (ORCID: https://orcid.org/0000-0003-3855-8651)
- Hernán Trimarchi (ORCID: https://orcid.org/0000-0002-6921-4811)
- Vladimı́r Tesař (ORCID: https://orcid.org/0000-0001-6982-0689)
- Bart Maes (ORCID: https://orcid.org/0000-0001-5084-5130)
- Hong Zhang (ORCID: https://orcid.org/0000-0003-4037-7497)
- Jürgen Floege (ORCID: https://orcid.org/0000-0001-7102-6150)
- Sean J. Barbour
- Xuelian Wei
- Roberto Pecoits-Filho
Institutions
- The University of Sydney (AU)
- University of British Columbia (CA)
- University of Leicester (GB)
- Pontifícia Universidade Católica do Paraná (BR)
- Yonsei University (KR)
- Peking University (CN)
- Charles University (CZ)
- Mount Elizabeth Novena Hospital (SG)
- Westmead Hospital (AU)
- University of Alabama at Birmingham (US)
- Institute of Post Graduate Medical Education and Research (IN)
- Peking University First Hospital (CN)
- Arbor Research Collaborative for Health (US)
- Juntendo University Urayasu Hospital (JP)
- George Institute for Global Health (IN)
- AZ Delta (BE)
- Hospital Británico de Buenos Aires (AR)
- Kocaeli Üniversitesi (TR)
- University of Pennsylvania (US)
- RWTH Aachen University (DE)
- Stanford University (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1056/nejmoa2510198
- Citations
- 15
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 21.46