HLA‐C <i> </i> <sup>∗</sup> 0304 Associates With Beneficial Gut Microbiota and Later Onset of Type 1 Diabetes in Pediatric Cohorts
Our study demonstrates that specific HLA class I subtypes (e.g., C <sup><i>∗</i></sup> 0304) may modulate T1DM onset through selective enrichment of beneficial gut microbiota. Elucidating the mechanisms by which HLA variants regulate mucosal immunity and coordinate HLA-microbiota-immune interactions holds significant potential for developing targeted interventions against T1DM pathogenesis.
Authors
- Yu Yang (ORCID: https://orcid.org/0000-0002-8988-0790)
- Lanwei Cui (ORCID: https://orcid.org/0000-0003-1541-8517)
- Zhenran Xu (ORCID: https://orcid.org/0000-0003-2718-6717)
- Feihong Luo (ORCID: https://orcid.org/0000-0002-6433-7994)
- Xiaoxiao Yuan (ORCID: https://orcid.org/0000-0003-2405-0101)
- Chengjun Sun (ORCID: https://orcid.org/0000-0001-6025-4801)
- Hongwei Du (ORCID: https://orcid.org/0000-0002-9744-098X)
- Guimei Li (ORCID: https://orcid.org/0000-0001-8372-3842)
- Linqi Chen (ORCID: https://orcid.org/0000-0002-1763-630X)
- Qiuyue Li (ORCID: https://orcid.org/0000-0003-0058-503X)
- Xiaojing Li (ORCID: https://orcid.org/0000-0003-1660-3108)
- Xiaojuan Chen (ORCID: https://orcid.org/0000-0002-2109-1277)
- Jing Wu (ORCID: https://orcid.org/0000-0002-1224-0912)
- Haiyan Wei (ORCID: https://orcid.org/0000-0003-1044-6594)
- Xin Fang (ORCID: https://orcid.org/0000-0003-2848-496X)
- Ruimin Chen (ORCID: https://orcid.org/0000-0003-4114-7706)
- Miaoying Zhang (ORCID: https://orcid.org/0000-0002-4160-3962)
Institutions
- Fujian Medical University (CN)
- Nanchang University (CN)
- Harbin Medical University (CN)
- Jilin University (CN)
- Soochow University (CN)
- Zhengzhou Children's Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Shandong Provincial Hospital (CN)
- First Hospital of Jilin University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Children's Hospital of Fudan University (CN)
- Shandong First Medical University (CN)
- Union Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Pediatric Diabetes
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/pedi/3013063
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fudan University
- National Science and Technology Major Project