Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis
As a tumor suppressor gene in osteosarcoma, P3H2 inhibits the malignant biological behavior of osteosarcoma by inhibiting the AKT/mTOR signaling axis.
Authors
- Ruilin Pan (ORCID: https://orcid.org/0000-0002-8268-739X)
- Jing Zhao (ORCID: https://orcid.org/0000-0001-5681-6058)
- Yanmei Cheng
- Lei Xiao (ORCID: https://orcid.org/0000-0002-0428-1749)
- Zihang Chen
- Pengju Feng (ORCID: https://orcid.org/0000-0002-5470-0403)
- Xiaofei Zheng (ORCID: https://orcid.org/0000-0001-7502-6131)
- Yiming Zhang (ORCID: https://orcid.org/0000-0001-5959-0963)
- Jian Guan (ORCID: https://orcid.org/0000-0003-1739-4328)
- Huajun Wang (ORCID: https://orcid.org/0000-0003-3936-7400)
- Nan Ru
Institutions
- Hebei Medical University (CN)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- University of Macau (MO)
- Third Hospital of Hebei Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Ministry of Education (TH)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Regenerative Medicine Institute (MX)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.tranon.2025.102569
- Citations
- 1
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81