Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Progressive Aortic Dilatation in Marfan Syndrome
Our findings support a crucial role of inverse agonist activity of ARB for the prevention of mechanical stress-induced AT<sub>1</sub> receptor activation and aortic aneurysm progression in Marfan syndrome mice.
Authors
- Hiroki Yagi (ORCID: https://orcid.org/0000-0001-6615-6196)
- Norifumi Takeda (ORCID: https://orcid.org/0000-0003-4818-3347)
- Tappei Takada (ORCID: https://orcid.org/0000-0002-3868-9320)
- Hiroshi Akazawa (ORCID: https://orcid.org/0000-0002-3574-9607)
- Tomomi Ueda (ORCID: https://orcid.org/0000-0003-2983-4503)
- Shun Okamura (ORCID: https://orcid.org/0009-0003-7317-9881)
- Ryo Matsuoka (ORCID: https://orcid.org/0000-0002-2317-5845)
- Akito Shindo (ORCID: https://orcid.org/0000-0001-8978-7804)
- Issei Komuro (ORCID: https://orcid.org/0000-0002-0714-7182)
- Akiko Saga-Kamo (ORCID: https://orcid.org/0000-0002-0203-3792)
- Kazutaka Ueda (ORCID: https://orcid.org/0000-0002-0509-1840)
- Masahiko Umei (ORCID: https://orcid.org/0000-0003-0331-5617)
- Hiroshi Kadowaki (ORCID: https://orcid.org/0000-0002-0462-0966)
- Qing Liu (ORCID: https://orcid.org/0000-0001-9021-7665)
- Sayo M Ito
Institutions
- Fudan University (CN)
- University of Tokyo Hospital (JP)
- Zhongshan Hospital (CN)
- The University of Tokyo (JP)
- University of Tennessee at Knoxville (US)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1161/atvbaha.125.322646
- Citations
- 2
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 3.63