Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer
In this trial, chest-wall irradiation did not result in higher overall survival than no chest-wall irradiation among patients with intermediate-risk, early breast cancer treated with mastectomy and contemporary adjuvant systemic therapy. (Funded by the Medical Research Council and others; SUPREMO ISRCTN Clinical Study Registry number, 61145589.).
Authors
- Nicola S. Russell (ORCID: https://orcid.org/0000-0003-3507-9620)
- Boon Chua (ORCID: https://orcid.org/0000-0002-7561-7174)
- David Cameron (ORCID: https://orcid.org/0000-0002-2717-7979)
- Lisa Barraclough (ORCID: https://orcid.org/0000-0001-7831-3582)
- Helen Westenberg
- Marjory Maclennan
- Karen Venables (ORCID: https://orcid.org/0000-0001-8829-2367)
- Joanna Dunlop (ORCID: https://orcid.org/0000-0001-5019-6118)
- Rhun Evans
- Nicole Sergenson (ORCID: https://orcid.org/0000-0003-2956-0282)
- Geertjan van Tienhoven (ORCID: https://orcid.org/0000-0002-2516-2263)
- Shulian Wang
- M. Hatton (ORCID: https://orcid.org/0000-0003-2778-7926)
- Susan Cleator (ORCID: https://orcid.org/0000-0003-3859-7888)
- Edwin Aird
- Richard Welch (ORCID: https://orcid.org/0000-0001-8298-8697)
- Jeremy Thomas (ORCID: https://orcid.org/0000-0002-4652-610X)
- Tracy McEleney
- Abdulla Alhasso (ORCID: https://orcid.org/0009-0000-7146-0299)
- Heather McCarty
- Eleanor J. Macdonald
- Kathleen Riddle
- Niall Anderson (ORCID: https://orcid.org/0000-0002-0033-1921)
- Tammy Piper (ORCID: https://orcid.org/0000-0002-1038-6467)
- Ye‐Xiong Li (ORCID: https://orcid.org/0000-0003-0985-235X)
- Coen Hurkmans (ORCID: https://orcid.org/0000-0003-2268-0492)
- Karen J. Taylor (ORCID: https://orcid.org/0000-0002-2265-5097)
- Linda Williams (ORCID: https://orcid.org/0000-0002-6317-1718)
- Virginia Wolstenholme
- Pamela Woodings
- N. Bayman (ORCID: https://orcid.org/0000-0002-9756-8676)
- R Sainsbury (ORCID: https://orcid.org/0000-0003-3117-3177)
- K. Geropantas
- John M.S. Bartlett (ORCID: https://orcid.org/0000-0002-0347-3888)
- Jackie Clarke
- Ian Kunkler
- Galina Velikova
- J. Michael Dixon
- Eldo T. Verghese
- J. Loncaster
- Peter Canney
- Andrew M. Hanby
- James A. Burns (ORCID: https://orcid.org/0009-0003-8422-4035)
- Fidelis Muturi
Institutions
- Belfast Health and Social Care Trust (GB)
- NHS Lothian (GB)
- University of Ulster (GB)
- Radboud University Nijmegen (NL)
- Imperial College Healthcare NHS Trust (GB)
- University of Aberdeen (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Barts Health NHS Trust (GB)
- Royal Derby Hospital (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Norfolk and Norwich University Hospital (GB)
- Hillingdon Hospitals NHS Foundation Trust (GB)
- Western General Hospital (GB)
- Beatson West of Scotland Cancer Centre (GB)
- Catharina Ziekenhuis (NL)
- St James's University Hospital (GB)
- Bolton NHS Foundation Trust (GB)
- Edinburgh Cancer Research (GB)
- Weston Park Cancer Centre (GB)
- Belfast City Hospital (GB)
- The Netherlands Cancer Institute (NL)
- UNSW Sydney (AU)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Public Health Scotland (GB)
- The Christie NHS Foundation Trust (GB)
- Radiotherapiegroep (NL)
- University Hospitals of Derby and Burton NHS Foundation Trust (GB)
- Amsterdam University Medical Centers (NL)
- Royal Bolton Hospital (GB)
- University College London (GB)
- Academia Sinica (TW)
- University of Amsterdam (NL)
- University of Edinburgh (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1056/nejmoa2412225
- Citations
- 12
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.23