Increased Avoidance Learning in Chronic Opioid Users
This cross-sectional study supports preclinical findings emphasizing the role of negative reinforcement in opioid addiction, although this has not been shown in humans before. The results indicate that negative reinforcement is relevant even in the early stages of opioid use, suggesting potential new avenues for prevention and treatment.
Authors
- Karen D. Ersche (ORCID: https://orcid.org/0000-0002-3203-1878)
- Herbert Görne
- Tsen Vei Lim (ORCID: https://orcid.org/0000-0002-6565-4326)
- Caspar J Geissler
- Christian Büchel
- Sylke Krenkel
Institutions
- Universität Hamburg (DE)
- Heidelberg University (DE)
- University of Cambridge (GB)
- Central Institute of Mental Health (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Institute for Interdisciplinary Medicine (DE)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.3271
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00