Diagnostic challenges of polyclonal B-cell lymphocytosis in an English Bulldog (PBLEB) and outcome following splenectomy

Polyclonal B-cell lymphocytosis of English Bulldogs (PBLEB) is a lymphoproliferative disorder associated with splenomegaly and hyperglobulinaemia. Information regarding both the degree of expected lymphocytic organ infiltration and possible treatment protocols is limited, and clinical overlap with neoplastic lymphoproliferative disease presents a diagnostic challenge. Here, we report and discuss the case of a 5-year-old English Bulldog with PBLEB, presenting with a marked gammopathy, marked splenomegaly and subsequent abdominal distension resulting in gastrointestinal clinical signs. We present extensive clinicopathological and histopathological data, demonstrate marked infiltration of tissues including the bone marrow, and document a favourable clinical outcome following splenectomy.