The causal mediating effect of smoking on the relationship between irritability and bipolar disorder: A two-step Mendelian randomization study
Smoking plays a mediating role in the potential causal pathway linking irritability and bipolar disorder, suggesting that smoking cessation interventions may possibly help mitigate the risk of bipolar disorder among individuals with heightened irritability.
Authors
- Enzhao Cong
- Jianhua Chen (ORCID: https://orcid.org/0000-0003-0326-3124)
- Yifeng Xu (ORCID: https://orcid.org/0000-0002-0403-1141)
- Xin Luo
- Qianying Hu sup sup (ORCID: https://orcid.org/0000-0001-5902-6457)
- Chaoyan Yue sup sup (ORCID: https://orcid.org/0000-0003-4030-0166)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Mental Health Center (CN)
- Shanghai Tenth People's Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Tobacco Induced Diseases
- Published
- 2025-11-07
- DOI
- https://doi.org/10.18332/tid/209615
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council