Dopaminergic and Opioid Systems Interact to Produce Peripheral Antinociception in Mice
Overall, the data suggest that opioid-mediated antinociception depends on the activation of the dopaminergic system. This demonstrates that pain modulation can be enhanced through the interaction of these systems. Controlling pain at a peripheral level by activating endogenous pathways could be a promising approach to pain management.
Authors
- Thiago Roberto Lima Romero (ORCID: https://orcid.org/0000-0001-9723-0395)
- Igor Dimitri Gama Duarte (ORCID: https://orcid.org/0000-0003-3891-5225)
- Flávia Cristina de Sousa Fonseca (ORCID: https://orcid.org/0000-0002-3794-0966)
- Bárbara Formiga Gonçalves de Queiroz (ORCID: https://orcid.org/0009-0004-0115-9811)
- Walace Cássio Pinto Barra (ORCID: https://orcid.org/0000-0002-9628-7290)
- A Irie (ORCID: https://orcid.org/0009-0007-5917-2607)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais (BR)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-10-28
- DOI
- https://doi.org/10.31083/jin44311
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais