Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway
POL mitigated murine spinal cord injury-induced neuroinflammation and oxidative stress through PI3K/AKT/mTOR signaling pathway activation. Furthermore, POL treatment contracted the glial scar expanse within the injury epicenter and fostered axonal regeneration coupled with myelin regeneration. Consequently, POL enhances post-SCI motor function and accelerates neural function restoration.
Authors
- Hongxiang Hong (ORCID: https://orcid.org/0000-0001-5920-9472)
- Tianyi Wang (ORCID: https://orcid.org/0009-0001-6509-5536)
- Qianqiu Li (ORCID: https://orcid.org/0009-0009-1231-2179)
- Mingjie Xia (ORCID: https://orcid.org/0009-0000-1566-3024)
- Zheng Zhou (ORCID: https://orcid.org/0000-0003-3433-751X)
- Zhiming Cui (ORCID: https://orcid.org/0009-0000-0359-3786)
- Jian Huang (ORCID: https://orcid.org/0009-0001-4188-4602)
- Guanhua Xu (ORCID: https://orcid.org/0009-0002-8272-1743)
- Q. Fu (ORCID: https://orcid.org/0009-0000-4969-0012)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-10-29
- DOI
- https://doi.org/10.31083/jin43900
- Citations
- 1
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.91