Effects of Resveratrol on Cardiomyocyte Hypoxia-reoxygenation Injury Induced by High Glucose and Its Relationship with NRG1/ErbB Pathway

Background Research has found that diabetes and cardiomyopathy are partially caused by hypoxia-reoxygenation damage to myocardial cells in a high-glucose environment. Resveratrol (RSV) exhibits protective effects on the cardiovascular system, and the neuregulin-1/erythroblastic leukemia viral oncogene homolog (NRG1/ErbB) pathway plays a crucial role in cardiac development and functional regulation. Purpose This study aims to explore the effect of RSV on myocardial cell hypoxia-reoxygenation injury caused by high glucose (HG) and its relationship with NRG1/ErbB. The relationship between the ErbB pathway can provide new ideas for preventing and treating diabetic cardiomyopathy. Materials and Methods The experimental mice were randomly divided into the negative control (NG) group, the HG group, the HG+H/R group, the 0.5 RSV group, the 1.0 RSV group, the 1.5 RSV group, the 1.5 RSV+NRG1 group, and the 1.5 RSV+NRG1+AG1478 group by a blind selection method. Cell proliferation, invasion, and expression of caspase-3, ErbB4, PI3K, Akt, MAPK, and reactive oxygen species (ROS) were detected. Results RSV can effectively reduce the apoptosis of myocardial injury caused by HG and can improve its activity; specific blocking of the NRG1 signaling pathway can reverse the protective effect of RSV on myocardial injury caused by HG to a certain extent, and activating NRG1 pathways can amplify their protective effects. Conclusion RSV can reduce the expression of caspase-3 through the NRG1/ErbB signaling pathway, not only reducing cell apoptosis but also reducing the hypoxia-reoxygenation injury of cardiomyocytes caused by HG to a certain extent, further playing a protective role in cardiomyocytes.