Genetic risk factors and clinical manifestations of systemic lupus erythematosus: Large‐scale analysis of genetic predisposition and disease subtypes
The findings demonstrate that known SLE risk gene variants play a role in the development of at least half of the ACR-82 criteria for SLE, indicating a future possibility of using genetics to predict a variety of disease sub-phenotypes in SLE.
Authors
- Martina Frodlund (ORCID: https://orcid.org/0000-0001-7522-5069)
- Pascal Pucholt (ORCID: https://orcid.org/0000-0003-3342-1373)
- Karoline Lerang
- Øyvind Molberg (ORCID: https://orcid.org/0000-0003-4493-8853)
- Andreas Jönsen (ORCID: https://orcid.org/0000-0002-4418-5786)
- Christopher Sjöwall (ORCID: https://orcid.org/0000-0003-0900-2048)
- Elisabet Svenungsson (ORCID: https://orcid.org/0000-0003-3396-3244)
- Lars Rönnblom (ORCID: https://orcid.org/0000-0001-9403-6503)
- Johanna K. Sandling (ORCID: https://orcid.org/0000-0003-1382-2321)
- Solbritt Rantapää‐Dahlqvist (ORCID: https://orcid.org/0000-0001-8259-3863)
- Anna Rudin (ORCID: https://orcid.org/0000-0002-4137-1276)
- Sarah Reid (ORCID: https://orcid.org/0000-0003-4065-6875)
- Dag Leonard (ORCID: https://orcid.org/0000-0002-6275-7282)
- Anders Bengtsson (ORCID: https://orcid.org/0000-0001-7752-0432)
- Iva Gunnarsson
- Ann‐Christine Syvänen
- Ahmed Sayadi
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Oslo University Hospital (NO)
- Karolinska University Hospital (SE)
- Lund University (SE)
- Science for Life Laboratory (SE)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- University of Gothenburg (SE)
- Umeå University (SE)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1111/joim.70040
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Svenska Sällskapet för Medicinsk Forskning
- Vetenskapsrådet
- Agnes och Mac Rudbergs Stiftelse
- Svenska Läkaresällskapet
- Reumatikerförbundet
- Landstinget i Uppsala län