Antiproliferative effects of Trigonostemon xyphophyllorides on renal cell carcinoma via the PI3K/AKT pathway
This study utilized <i>in vitro</i> experimental validation techniques to establish that TX exerts its anti-proliferative effects by activating the PI3K-AKT signaling pathway. These findings elucidate the mechanism of TX action and provide a scientific basis for its prospective contemporary utilization.
Authors
- Tingting Chen (ORCID: https://orcid.org/0000-0003-1427-2683)
- Bai Ling
- Yuru Yang
- Jinyan He (ORCID: https://orcid.org/0000-0002-6190-4535)
- Andong Wang (ORCID: https://orcid.org/0000-0003-2281-7946)
- Xiaotian Cheng
Institutions
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Yancheng First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fphar.2025.1594461
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province