Green synthesis of silver nanoparticles using Saudi Xanthium strumarium extract: anticancer potential against breast and lung cancer cells
XT-AgNPs demonstrated notable cytotoxic effects on MCF-7 and A-549 cells with IC<sub>50</sub> values of 44.3 and 57.4 μg/mL, respectively. Morphological and DCFH-DA analyses revealed the effect of XT-AgNPs in reducing the cell proliferation and inducing ROS generation. GC/MS analysis was conducted to identify the phytochemicals present in the extract which showed 29 peaks of phytoconstituents. These 27 phytoconstituents were further analyzed by <i>in silico</i> studies, molecular docking study was carried out for all phytoconstituents, and compounds having maximum binding affinity were analyzed for their ADMET profile. Overall, the results highlight the anticancer properties of XT-AgNPs, indicating their potential as an effective agent in human breast and lung cancer management.
Authors
- Raha Orfali (ORCID: https://orcid.org/0000-0002-9421-4127)
- Hanan Y. Aati (ORCID: https://orcid.org/0000-0003-1598-2273)
- Shagufta Perveen (ORCID: https://orcid.org/0000-0002-3318-9861)
- Nida Nayyar Farshori (ORCID: https://orcid.org/0000-0003-1310-3351)
- Jawaher Alqahtani (ORCID: https://orcid.org/0000-0002-3640-9612)
- Areej Mohammad Al‐Taweel
Institutions
- University of Wisconsin–Madison (US)
- King Saud University (SA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.3389/fphar.2025.1653711
- Citations
- 1
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- King Saud University