Divergent Prognostic Value of Primary Tumor Segmentation Metrics on Baseline FDG PET/CT in Colorectal Cancer
Segmentation of the primary tumor on baseline FDG PET/CT provides valuable prognostic information in CRC. While cranio-caudal extension was the strongest prognostic biomarker of short-term treatment response, MTV was independently associated with long-term outcomes, particularly progression-free survival. These findings highlight the complementary prognostic roles of morphological and metabolic tumor features and support the integration of PET/CT-based biomarkers into personalized treatment strategies for colorectal cancer.
Authors
- Ken Kudura
- Nando Ritz
- Tim Kutzker
- Robert Foerster (ORCID: https://orcid.org/0000-0002-7664-9207)
- M. Strauß (ORCID: https://orcid.org/0000-0003-1872-2397)
- Wolfgang Harms
- Rebecca Engel
- Yves Schaulin
- Arkadiusz Miszczyszyn
Institutions
- University of Bern (CH)
- Université Libre de Bruxelles (BE)
- University of Basel (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Humboldt-Universität zu Berlin (DE)
- CHU Dinant Godinne UCL Namur (BE)
- Kantonsspital Winterthur (CH)
- St. Claraspital (CH)
- UCLouvain (BE)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-06
- DOI
- https://doi.org/10.3390/cancers17213592
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00