Pro-gastrin releasing peptide as a tumor marker of medullary thyroid carcinoma: a comparative bivariate meta-analysis
ProGRP demonstrates high specificity but lower sensitivity than CT for MTC diagnosis and surveillance. Although not a replacement for CT, ProGRP may serve as a valuable complementary biomarker, particularly in inconclusive cases. Harmonization of assays and prospective validation are required to define universal thresholds and integrate ProGRP into multimarker diagnostic algorithms.
Authors
- Petra Petranović Ovčariček (ORCID: https://orcid.org/0000-0003-1946-2128)
- Federica D’Aurizio (ORCID: https://orcid.org/0000-0003-2311-859X)
- Luca Giovanella (ORCID: https://orcid.org/0000-0003-0230-0974)
- Alfredo Campennì (ORCID: https://orcid.org/0000-0002-0177-939X)
- Frederik A. Verburg (ORCID: https://orcid.org/0000-0003-1401-1993)
Institutions
- University of Messina (IT)
- University of Udine (IT)
- University of Zagreb (HR)
- Erasmus MC (NL)
- University Hospital of Zurich (CH)
- Luzerner Kantonsspital (CH)
- Clinica Luganese Moncucco (CH)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1515/cclm-2025-0867
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00