Clinical performance assessment of the Papilloplex HR-HPV assay on self-taken urine and vaginal swab samples: findings from a multicentre European study
The clinical sensitivity of the Papilloplex HR-HPV test was similar on self-collected vaginal swabs and urine compared with CS; clinical specificity on urine was similar to CS yet lower on vaginal samples. Cut-off optimisation resulted in a similar assay specificity on vaginal swabs and CS with no significant detriment to sensitivity.
Authors
- Chiara Giubbi (ORCID: https://orcid.org/0000-0001-6112-7572)
- Roberto Pietri
- Fabio Bottari (ORCID: https://orcid.org/0000-0003-1838-0163)
- Anna Daniela Iacobone (ORCID: https://orcid.org/0000-0001-6909-1228)
- Kate Cuschieri (ORCID: https://orcid.org/0000-0002-2604-3928)
- Ardashel Latsuzbaia (ORCID: https://orcid.org/0000-0002-7361-3081)
- Clementina Cocuzza (ORCID: https://orcid.org/0000-0001-6166-1134)
- Hana McMahon
- F. Salinaro
- Franco Odicino (ORCID: https://orcid.org/0000-0001-8870-4739)
- Marianna Martinelli (ORCID: https://orcid.org/0000-0003-2273-6986)
- Andrea Piana (ORCID: https://orcid.org/0000-0002-6609-8886)
- Marc Arbyn (ORCID: https://orcid.org/0000-0001-8434-8263)
Institutions
- NHS Lothian (GB)
- University of Sassari (IT)
- Centro Cardiologico Monzino (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- MRC Centre for Reproductive Health (GB)
- Sciensano (Belgium) (BE)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
- University of Brescia (IT)
- University of Edinburgh (GB)
Publication Details
- Journal
- Journal of Clinical Pathology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1136/jcp-2025-210211
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00